High-Concentration Antioxidant & Cognitive Support

Ki Science’s Fisetin 200 is a high-concentration extract sourced from the Smoke Tree — providing a potent dose of this naturally occurring plant flavonoid.

Fisetin is a flavonoid polyphenol, which is part of a larger group of chemical compounds known as flavonoids. Flavonoids are present in many plants and perform various biological functions, including protecting plants from UV radiation, pathogens, and herbivores. Fisetin is known for its bright yellow color and is most commonly found in various types of fruits and vegetables. In recent years, it has received considerable attention from researchers due to its potential health benefits, which include anti-inflammatory, antioxidant, and neuroprotective effects.

Key Benefits

• Antioxidant and anti-inflammatory support

• Supports brain and nerve health

• Boosts immune system function

• May support blood glucose regulation

Pure & Clean Formula

• 98% pure Fisetin from Smoke Tree extract

• Gluten-free

• Lactose-free

• Non-GMO

• Vegetarian

• No artificial flavours

• Made in the UK

What Does Taking Fisetin Feel Like?

The effects of fisetin are very subtle. Remember, fisetin isn't a drug, so it won't elicit a strong or immediate response. It's a dietary supplement that may help you boost your intake of this beneficial flavonol that supports cellular health.

This distinction is important to remember as you begin introducing fisetin into your daily routine and will help mitigate expectations with dietary supplements.

When you begin taking fisetin, you might not feel a dramatic change. The advantages of fisetin build up over time as it starts to support your body's natural systems.

Fisetin has been found to have high antioxidant potential, which means it helps to neutralize free radicals and reduce oxidative stress at the cellular level. This process supports cell health and lifespan, contributing to overall well-being [2].

For many regular fisetin users, the most noticeable effects of fisetin are subtle improvements in energy levels and cognitive function. This might mean having more consistent energy throughout the day without the sharp peaks and crashes often associated with caffeine or sugar. This steady energy can help you feel more alert and focused, making staying productive and engaged in your daily activities easier.

When's the Best Time of Day to Take Fisetin?

We recommend taking fisetin in the morning with water and with food in your stomach. There's no one right way to time your fisetin doses. But it mainly depends on the sort of routine you're looking for.

Here are some advantages to taking your fisetin in the morning, mid-day, and night.

- Morning Dosing

Taking fisetin in the morning may be the best option to kickstart your day with a health boost.

Morning dosing may support a feeling of alertness, provide steady energy throughout the day, and help you get in the right mindset for setting and maintaining healthy lifestyle choices.

This can be especially helpful for older adults or anyone looking to establish a consistent routine for their supplements.

- Mid-Day Dosing

Daytime dosing of fisetin can be advantageous for maintaining consistent energy levels and focus. If you experience midday energy slumps, taking fisetin around lunchtime may help sustain your energy and mental clarity throughout the afternoon.

- Night-time Dosing

Nighttime dosing of fisetin may support recovery by leveraging its potential to combat oxidative stress accumulated throughout the day, aiding cellular repair and overall recovery.

Where is fisetin found?

Fisetin is found naturally in many types of fruits and vegetables. Some of the main sources include:

Strawberries – The richest source of fisetin among commonly consumed fruits. They can contain up to 160 micrograms of fisetin per gram.

Apples – They contain a smaller amount, but are easily accessible and often consumed.

Grapes – Red grapes, especially their skins, are another important source of fisetin.

Tomatoes – A rich source of fisetin in vegetables, easy to include in your daily diet.

Onions – Also contain a significant amount of this compound, especially yellow onions.

Japanese Persimmons (Kaki) – An exotic fruit that is another source of fisetin.

How to get it?

To get enough fisetin, it is important to include foods rich in this substance in your diet. But dietary supplements can actually provide a concentrated form of this compound.

Benefits of fisetin

Fisetin is the subject of intense scientific research due to its diverse biological effects. Fisetin alone is not easily absorbed by the body, so adding fats while consuming fisetin can help it become more bioavailable. However, avoid taking fisetin supplements if you are taking blood thinners.

Anti-inflammatory properties

Inflammation is the body’s natural response to injury or infection, but chronic inflammation can lead to a variety of health problems. Fisetin has anti-inflammatory properties, which can help reduce inflammatory responses in the body. Studies have shown that fisetin can inhibit the production of inflammatory molecules, which can have a positive impact on the health of the cardiovascular system and other organs.1

The anti-inflammatory effects of fisetin have been demonstrated in various studies, in which fisetin was found to be able to reduce levels of pro-inflammatory cytokines and other mediators of inflammation.1 In this way, fisetin may help prevent chronic inflammatory diseases, such as arthritis or inflammatory bowel disease.

Neuroprotection

Neuroprotection is one of the most important areas of research on fisetin. Fisetin may support brain health by protecting neurons from damage and supporting cognitive function. Studies also suggest that fisetin may improve memory and protect the brain from neurodegenerative diseases.2

Fisetin is able to cross the blood-brain barrier, which allows it to act directly on brain cells. Research shows that fisetin may support the survival of neurons and reduce the accumulation of harmful proteins associated with neurodegenerative diseases, such as Alzheimer's disease.2

Antidiabetic effects

Fisetin may also have a positive impact on blood sugar levels and insulin sensitivity, which is especially helpful for people with diabetes or metabolic syndrome. Fisetin may support healthy glucose regulation and improve pancreatic function.

Fisetin has the ability to reduce blood sugar levels and improve insulin resistance. These effects are mediated through various mechanisms, including increasing insulin receptor expression and inhibiting enzymes involved in glucose metabolism.

Antioxidant

Fisetin is a potent antioxidant, meaning it helps neutralize free radicals in the body. Free radicals are unstable molecules that can damage cells and contribute to the aging process and various diseases. The antioxidant effects of fisetin may help protect cells against oxidative stress, which is a condition in which there is an excess of free radicals in the body.

Oxidative stress is associated with a number of chronic diseases, including cardiovascular disease and neurodegenerative diseases. Due to its antioxidant properties, fisetin helps reduce the risk of these diseases by protecting cells from damage.3

Immune system support

Fisetin also has immunomodulatory effects, meaning it influences the function of the immune system. It has the ability to support the body’s defenses against infections and improve the overall immune response.

Fisetin can increase the activity of immune cells, such as T lymphocytes and macrophages, while at the same time reducing the production of pro-inflammatory cytokines. In this way, fisetin can help maintain the balance of the immune system and prevent excessive inflammatory reactions.

Conclusion

Fisetin is a flavonoid polyphenol with a number of potential health benefits, confirmed by scientific studies. It is found in fruits and vegetables such as strawberries, apples, grapes, tomatoes and onions, and is also available in the form of dietary supplements. Due to its antioxidant properties, fisetin protects cells against oxidative stress and reduces the risk of chronic diseases. Its anti-inflammatory effects may help prevent inflammatory diseases, while its neuroprotective properties support brain health and may help prevent neurodegenerative diseases. Fisetin's antidiabetic effects help regulate blood sugar levels and improve insulin sensitivity, and its immunomodulatory properties support the immune system.

1 CHEN, L.-J., et al. Fisetin attenuates the inflammatory response in a murine model of sepsis by inhibiting the NF-κB pathway. Journal of Ethnopharmacology [online]. 2015, 172, 89-98 [cit. 2024-06-20]. https://link.springer.com/article/10.1007/s12263-009-0142-5.

2 MAHER, P. Modulation of multiple pathways involved in maintaining neuronal function during aging by fisetin. Genes & Nutrition [online]. 2009, 4(4), 297-307 [cit. 2024-06-20]. https://link.springer.com/article/10.1007/s12263-009-0142-5.

3 SYED, D. N., et al. Fisetin: A Dietary Antioxidant for Health Promotion . Antioxidants & Redox Signaling [online]. 2013, 19(2), 151-162 [cit. 2024-06-20]. https://www.liebertpub.com/doi/10.1089/ars.2012.4901.

Source: Adhami VM, Syed DN, Khan N, Mukhtar H. Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem Pharmacol. 2012 Nov 15;84(10):1277-81.